Gene information
Official symbol TIMP1
Official full name TIMP metallopeptidase inhibitor 1
Gene type protein-coding gene
ChromosomeXp11.3
Alias symbolEPO
Previous symbolTIMP; CLGI
Gene familyTissue inhibitor of metallopeptidases
Resources
Entrez Gene 7076
HGNC HGNC:11820
Ensembl ENSG00000102265
Vega OTTHUMG00000021447
UCSC uc004dif.4
GO terms: 56 records
GO Description Category LogP Number of genes Detail
GO:0001501 skeletal system development GO Biological Processes -17.2073293 69 More
GO:0001775 cell activation GO Biological Processes -43.3738118 71 More
GO:0002020 protease binding GO Molecular Functions -28.8254555 31 More
GO:0002246 wound healing involved in inflammatory response GO Biological Processes -8.11497800 5 More
GO:0004857 enzyme inhibitor activity GO Molecular Functions -18.4005452 35 More
GO:0004866 endopeptidase inhibitor activity GO Molecular Functions -20.0646267 27 More
GO:0005125 cytokine activity GO Molecular Functions -54.7097150 57 More
GO:0005604 basement membrane GO Cellular Components -9.30297759 21 More
GO:0005788 endoplasmic reticulum lumen GO Cellular Components -47.2996164 57 More
GO:0006954 inflammatory response GO Biological Processes -86.5569367 100 More
GO:0007568 aging GO Biological Processes -23.5429582 29 More
GO:0008083 growth factor activity GO Molecular Functions -26.3260872 31 More
GO:0009314 response to radiation GO Biological Processes -9.77450393 26 More
GO:0009411 response to UV GO Biological Processes -7.07745319 13 More
GO:0009416 response to light stimulus GO Biological Processes -4.81054429 15 More
GO:0009611 response to wounding GO Biological Processes -63.1714102 77 More
GO:0009725 response to hormone GO Biological Processes -49.1091700 138 More
GO:0009895 negative regulation of catabolic process GO Biological Processes -10.3621088 43 More
GO:0010466 negative regulation of peptidase activity GO Biological Processes -24.1438543 35 More
GO:0010951 negative regulation of endopeptidase activity GO Biological Processes -24.7873219 35 More
GO:0030162 regulation of proteolysis GO Biological Processes -41.2267045 73 More
GO:0030312 external encapsulating structure GO Cellular Components -73.3689453 93 More
GO:0030414 peptidase inhibitor activity GO Molecular Functions -19.6181890 27 More
GO:0030545 signaling receptor regulator activity GO Molecular Functions -87.4728446 102 More
GO:0030546 signaling receptor activator activity GO Molecular Functions -90.4065983 101 More
GO:0031012 extracellular matrix GO Cellular Components -73.4416071 93 More
GO:0031091 platelet alpha granule GO Cellular Components -43.3287145 36 More
GO:0031093 platelet alpha granule lumen GO Cellular Components -40.0105787 31 More
GO:0031330 negative regulation of cellular catabolic process GO Biological Processes -6.88355184 32 More
GO:0031983 vesicle lumen GO Cellular Components -60.5757669 68 More
GO:0034644 cellular response to UV GO Biological Processes -5.54644403 9 More
GO:0034774 secretory granule lumen GO Cellular Components -58.3093741 66 More
GO:0040013 negative regulation of locomotion GO Biological Processes -30.7871461 81 More
GO:0042060 wound healing GO Biological Processes -56.2139708 65 More
GO:0042176 regulation of protein catabolic process GO Biological Processes -8.45353494 23 More
GO:0042177 negative regulation of protein catabolic process GO Biological Processes -5.18322511 10 More
GO:0043086 negative regulation of catalytic activity GO Biological Processes -41.1437610 130 More
GO:0043434 response to peptide hormone GO Biological Processes -26.1739008 69 More
GO:0045861 negative regulation of proteolysis GO Biological Processes -27.9905009 43 More
GO:0048018 receptor ligand activity GO Molecular Functions -91.0736151 101 More
GO:0048771 tissue remodeling GO Biological Processes -15.8777137 28 More
GO:0051043 regulation of membrane protein ectodomain proteolysis GO Biological Processes -16.3022563 12 More
GO:0051045 negative regulation of membrane protein ectodomain proteolysis GO Biological Processes -7.69370672 5 More
GO:0051216 cartilage development GO Biological Processes -10.5011549 17 More
GO:0051346 negative regulation of hydrolase activity GO Biological Processes -26.0030636 42 More
GO:0052547 regulation of peptidase activity GO Biological Processes -35.5643317 55 More
GO:0052548 regulation of endopeptidase activity GO Biological Processes -34.9486589 53 More
GO:0060205 cytoplasmic vesicle lumen GO Cellular Components -59.3932782 67 More
GO:0061134 peptidase regulator activity GO Molecular Functions -19.3582235 29 More
GO:0061135 endopeptidase regulator activity GO Molecular Functions -19.1908633 27 More
GO:0061448 connective tissue development GO Biological Processes -12.1108226 21 More
GO:0062023 collagen-containing extracellular matrix GO Cellular Components -67.6170082 80 More
GO:0071482 cellular response to light stimulus GO Biological Processes -4.67282705 9 More
GO:0090594 inflammatory response to wounding GO Biological Processes -8.11856573 7 More
GO:1901652 response to peptide GO Biological Processes -34.9047734 89 More
GO:2000241 regulation of reproductive process GO Biological Processes -4.23306387 21 More
KEGG pathways: 1 record
KEGG Description Category LogP Number of genes Detail
hsa04066 HIF-1 signaling pathway KEGG Pathway -20.6790877 23 More
Related studies: 14 records
Molecular factor Omics type Application Objective MI type Reference
metalloproteinase inhibitor 1 proteomics left ventricular remodeling[prognosis (bad)] acute ST elevation myocardial infarction Hirohata S et al. Heart. 1997
metalloproteinase inhibitor 1 proteomics myocardial infarction[diagnosis] myocardial infarction Cavusoglu E et al. Am Heart J. 2006
metalloproteinase inhibitor 1 proteomics myocardial infarction[diagnosis] myocardial infarction Webb CS et al. Circulation. 2006
metalloproteinase inhibitor 1 proteomics ventricular fibrillation[prognosis (bad)] acute ST elevation myocardial infarction Elmas E et al. Clin Chem Lab Med. 2007
metalloproteinase inhibitor 1 proteomics acute myocardial infarction[diagnosis] acute myocardial infarction Halapas A et al. Clin Chem Lab Med. 2008
metalloproteinase inhibitor 1 proteomics good predictor death;heart failure[prognosis (bad)] acute myocardial infarction Kelly D et al. Eur Heart J. 2008
metalloproteinase inhibitor 1 proteomics acute ST elevation myocardial infarction[diagnosis] acute ST elevation myocardial infarction Tan J et al. Clin Cardiol. 2008
metalloproteinase inhibitor 1 proteomics acute myocardial infarction[diagnosis] acute myocardial infarction Dinh W et al. Int Heart J. 2009
metalloproteinase inhibitor 1 proteomics acute myocardial infarction[diagnosis] acute myocardial infarction Buduneli E et al. J Periodontol. 2011
metalloproteinase inhibitor 1 proteomics left ventricular remodeling[prognosis (bad)] acute ST elevation myocardial infarction Tan J et al. Yonsei Med J. 2012
metalloproteinase inhibitor 1 proteomics left ventricular dysfunction[prognosis (bad)] ST elevation myocardial infarction Goldbergova MP et al. Genet Test Mol Biomarkers. 2012
metalloproteinase inhibitor 1 proteomics acute heart failure[prognosis (bad)] ST elevation myocardial infarction Goldbergova MP et al. Genet Test Mol Biomarkers. 2012
metalloproteinase inhibitor 1 proteomics left ventricular remodeling[prognosis (bad)] acute ST elevation myocardial infarction Pecherina T et al. Diagnostics (Basel). 2020
metalloproteinase inhibitor 1 proteomics poor predictor major adverse cardiovascular events[prognosis (bad)] acute myocardial infarction Kelly D et al. Am J Cardiol. 2010
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